Cardiovascular Health · Article 01

Hypertension
(High Blood Pressure)

Silent, common, and one of the most consequential conditions in UK health — here is what the evidence shows about blood pressure, what the numbers mean, and how it is managed.

8 minute read
Evidence-based
Sources: NICE · WHO · Lancet · Cochrane · NHS · ONS
⚕️

Health education — not medical advice. Anything personally relevant is a conversation for you to have with your GP or healthcare professional.

1

What is it?

High blood pressure — known medically as hypertension — means the force of blood pushing against the walls of the arteries is consistently too high. Think of it like water pressure in a hosepipe: if the pressure is always too strong, over time it starts to damage the pipe itself.

Blood pressure is recorded as two numbers. The top number (systolic) measures the pressure when the heart beats. The bottom number (diastolic) measures the pressure between beats when the heart is resting. A reading is written as, for example, 120/80 mmHg (millimetres of mercury — the standard unit of pressure measurement) — said as "120 over 80."

A reading of 140/90 mmHg or above, confirmed on more than one occasion, is how hypertension is clinically defined in UK practice. Many people have no symptoms at all — which is why it is often described as a silent condition. It can be present for years without any awareness of it.

📖 Key Terms

Systolic pressureThe top number in a blood pressure reading — the pressure in the arteries when the heart beats.
Diastolic pressureThe bottom number — the pressure in the arteries between heartbeats, when the heart is resting.
mmHgMillimetres of mercury — the unit used to measure blood pressure, written as for example 120/80 mmHg.
ABPM (Ambulatory Blood Pressure Monitoring)A portable monitor worn for 24 hours that records blood pressure automatically throughout the day and night — giving a more accurate picture than a single clinic reading.
White coat hypertensionWhen blood pressure readings are elevated in a medical setting due to anxiety or stress, but normal at other times.
Cardiovascular disease (CVD)An umbrella term for conditions affecting the heart and blood vessels, including heart attack, stroke, heart failure, and coronary heart disease.
ECG (Electrocardiogram)A simple, painless test recording the heart's electrical activity — used to check for signs of strain or damage.
ACE inhibitors / ARBsTwo types of blood pressure medication that relax blood vessels. ACE inhibitors (e.g. ramipril) and ARBs (angiotensin receptor blockers — e.g. losartan) are often first-line in UK practice for younger adults.
Calcium channel blockersBlood pressure medicines (e.g. amlodipine) that relax and widen blood vessels by reducing calcium entering the vessel walls.
Thiazide-like diureticsA type of "water tablet" (e.g. indapamide) that lowers blood pressure by helping the kidneys remove excess fluid and salt.
2

Why does it matter?

1 in 3
UK adults has high blood pressure
Rising to around 60% of those aged 65 and over, and 66–71% of adults aged 75 and over.1
10M
deaths per year globally — more than any other single condition
Hypertension drives cardiovascular mortality worldwide through stroke, heart attack, heart failure, and kidney disease.3
600M
people worldwide are unaware they have it
Of an estimated 1.4 billion adults globally with hypertension, around 600 million have no awareness of their condition — reflecting its symptom-free nature.2
10%
reduction in major cardiovascular events
The risk reduction associated with just a 5 mmHg fall in systolic blood pressure — a modest change achievable through lifestyle or medication.4

Raised blood pressure puts constant extra strain on the heart, arteries, brain, kidneys, and eyes. Over time this cumulative damage is significant — even in the complete absence of symptoms. Hypertension is one of the leading causes of stroke, heart attack, heart failure, and chronic kidney disease in the UK.

The scale of undetected hypertension — both in the UK and globally — underlines why blood pressure checking in routine healthcare contacts matters. The condition is treatable, the evidence base is strong, and the cardiovascular benefit of even modest reductions in blood pressure is well established.

3

What your doctor might do

Confirming the diagnosis

In UK practice, a 24-hour blood pressure monitor worn at home — ambulatory blood pressure monitoring (ABPM) — is the standard approach to confirming a hypertension diagnosis. This provides a more accurate picture of blood pressure across everyday activity than a single clinic reading, and avoids the effect of white coat hypertension, where the clinical setting temporarily elevates readings through anxiety or stress.

Where ABPM is not suitable, home readings taken twice a day over several days are used instead.

Checking for organ effects and cardiovascular risk

Assessment typically includes blood tests, a urine test, and sometimes a heart trace (ECG — electrocardiogram — recording the heart's electrical activity) to establish whether elevated blood pressure has affected the kidneys or heart. An eye examination may also be included, as the small blood vessels at the back of the eye can show early signs of hypertensive damage.

Together these investigations provide an overall picture of cardiovascular risk — assessed using a validated risk calculator as part of standard UK clinical practice.

Management — lifestyle and medication

The approach depends on how high blood pressure is and what other health factors are present. For many people, lifestyle measures alone produce meaningful reductions — salt reduction, weight management, regular aerobic exercise, reduced alcohol intake, and smoking cessation are all recognised as having evidence-based blood pressure-lowering effects.

Where medication is indicated, UK practice follows NICE guideline NG136,7 which identifies three main drug classes depending on age and clinical factors: ACE inhibitors or ARBs, calcium channel blockers, or thiazide-like diuretics. Management on a combination of two or more is common.

Once treatment is established, blood pressure monitoring continues to confirm that targets are being achieved. In UK practice, the target for most people under 80 is below 140/90 mmHg in clinic (or below 135/85 mmHg on home monitoring). For those aged 80 and over, targets are slightly higher — below 150/90 mmHg in clinic, or below 145/85 mmHg on home monitoring — in line with NICE NG136.7

4

What the research shows

Blood pressure reduction and cardiovascular risk — the BPLTT Collaboration
The Lancet · 2021
Blood Pressure Lowering Treatment Trialists' Collaboration · The Lancet · 2021
Key finding
10%
lower risk of major cardiovascular events
per 5 mmHg reduction in systolic blood pressure — regardless of prior cardiovascular disease
This large analysis pooled data from hundreds of thousands of participants across randomised trials. A 5 mmHg reduction in systolic blood pressure (the top reading) produced a consistent 10% reduction in major cardiovascular events — including stroke, heart attack, and heart failure — across all participant groups, whether or not existing cardiovascular disease was present at baseline. This finding underpins the evidence base for treating hypertension across all levels of cardiovascular risk.
Blood Pressure Lowering Treatment Trialists' Collaboration. The Lancet. 2021. DOI: 10.1016/S0140-6736(21)00590-0
Blood pressure-lowering medication in adults aged 60 and over
Cochrane Review
Cochrane Database of Systematic Reviews · 16 trials · ~27,000 participants ⚑ Full citation to be verified
Key finding
16
trials confirmed reduced mortality and stroke risk in over-60s
~27,000 participants — evidence rated moderate to high certainty
A systematic review of 16 randomised controlled trials involving nearly 27,000 adults aged 60 and over found that blood pressure-lowering medication reduced overall mortality and substantially reduced the risk of stroke and heart attack in this age group. The quality of evidence was rated moderate to high certainty — providing clear support for treating hypertension in older adults rather than accepting elevated readings as an inevitable feature of ageing.
Cochrane Database of Systematic Reviews. ⚑ Full citation to be verified before publication.
Mild hypertension without cardiovascular disease — ongoing evidence debate
Cochrane · 2025
Cochrane Database of Systematic Reviews · Updated 2025 ⚑ Full citation to be verified
Key finding
Limited
evidence for medication reducing death or heart attack in lower-risk mild hypertension
blood pressure 140–159/90–99 mmHg · no existing CVD · stroke risk reduction may still occur
For people with mild hypertension (blood pressure 140–159/90–99 mmHg — millimetres of mercury — the standard pressure unit) and no existing cardiovascular disease, this updated Cochrane review found that current evidence for medication reducing overall mortality or heart attack risk in this lower-risk group remains limited, though there may be some reduction in stroke risk. This is an active area of research — the finding does not indicate that medication is inappropriate in this group, but rather that individual cardiovascular risk profile strongly influences the likely benefit.
Cochrane Database of Systematic Reviews, 2025. ⚑ Full citation to be verified before publication.
NICE guideline NG136 — hypertension in adults: diagnosis and management
NICE Guideline
National Institute for Health and Care Excellence · NG136 · Last updated 2025
UK treatment threshold
10%
10-year cardiovascular risk — the threshold for offering medication
in adults under 80 with confirmed hypertension — alongside lifestyle measures
NICE NG136 is the primary UK clinical framework for managing hypertension. Key recommendations include the use of ABPM for diagnosis, a risk-based approach to medication decisions (offering treatment when 10-year cardiovascular risk is 10% or more in those under 80), and treatment targets of below 140/90 mmHg in clinic for most adults under 80, rising to below 150/90 mmHg for those aged 80 and over. Lifestyle measures — including salt reduction, weight management, exercise, reduced alcohol, and smoking cessation — are an integral part of management at all stages.
🔑 Putting it all together

Hypertension is one of the most common and most consequential conditions in the UK — affecting around 1 in 3 adults and driving enormous numbers of strokes, heart attacks, and episodes of kidney disease each year. Its defining feature is silence: most people have no symptoms, and diagnosis typically comes through routine checking rather than any clinical warning.

The evidence for treatment is strong. Even modest reductions in blood pressure — as little as 5 mmHg systolic — produce meaningful reductions in cardiovascular events across all risk groups. Lifestyle measures have real, quantifiable effects and are a recognised component of management at every stage. Where medication is indicated, UK practice follows a well-established NICE-guided pathway.

Understanding what hypertension is, what the numbers mean, and how it is managed in UK practice is the foundation for any informed conversation about blood pressure — whether that is at a routine check, following an incidental finding, or after a formal diagnosis. That conversation belongs with a GP or healthcare professional.

About the author — Dr Paul spent over twenty years as an NHS GP before retiring in 2019. helf.school exists to give every person access to clear, honest, evidence-based health education. Read more about Dr Paul →

References

1
NHS Digital. Health Survey for England 2022. NHS Digital, 2023. ONS. Risk factors for undiagnosed high blood pressure in England, 2015–2019. Office for National Statistics, 2021.
2
World Health Organization. Global Hypertension Report 2024. WHO, Geneva, 2024.
3
World Health Organization. Global Hypertension Report 2023. WHO, Geneva, 2023.
4
Blood Pressure Lowering Treatment Trialists' Collaboration. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure. The Lancet. 2021;397(10285):1625–1636.
5
Cochrane Database of Systematic Reviews. Blood pressure lowering medication for adults aged 60 and over. ⚑ Full citation to be verified before publication.
6
Cochrane Database of Systematic Reviews. Pharmacotherapy for mild hypertension. Updated 2025. ⚑ Full citation to be verified before publication.
7
National Institute for Health and Care Excellence. Hypertension in adults: diagnosis and management. NICE guideline NG136. Last updated 2025.